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Background: We previously introduced a method based on post hoc pairwise comparisons toanalyze gene expression responses. This method utilized directed graphs torepresent gene response to all treatment pairs. It has been found useful inidentifying structure-activity relationships among drugs and differentiatinggenes sharing similar functional pathways. Directed graphs are descriptive,visually expressive and can benefit subsequent functional analysis. Results:mDAG is a web-based software package based on this established method for theanalysis, visualization, and interpretation of patterns of responses in geneexpression data involving multiple treatments. Genes with the same directedgraph patterns hypothetically share similar biological function, which may befurther analyzed using external tools. To facilitate subsequent functionalanalysis, several well-known tools have been incorporated into mDAG to helpusers explore hypotheses about gene function and regulation. This tool isuseful for any studies that analyze comparatively response patterns in gene expression data with multiple treatments chemicals, cell types, etc

Availability:The server-personal-demo software is freely available at http:-cetus.cs. memphis.edu-mdag.

KEYWORDS

Gene Expression; Directed Graph; Pairwise Comparison

Cite this paper

Vo, N. , Sutter, T. and Phan, V. 2013 mDAG: A web tool for analyzing, visualizing, and interpreting response patterns in gene expression data with multiple treatments. Advances in Bioscience and Biotechnology, 4, 706-709. doi: 10.4236-abb.2013.46093.





Autor: Nam S. Vo, Thomas R. Sutter, Vinhthuy Phan

Fuente: http://www.scirp.org/



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