Association between Single Nucleotide Polymorphisms SNPs and Toxicity of Advanced Non-Small-Cell Lung Cancer Patients Treated with ChemotherapyReportar como inadecuado




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New therapeutic approaches are being developed based on the findings that several genetic abnormalities underlying non-small-cell lung cancer NSCLC could influence chemosensitivity. In this study, we assessed whether polymorphisms in genes of nucleotide excision repair NER pathway, including ERCC5, ERCC6, MMS19L, CCNH, XPC, RRM1, can affect the tolerability of platinum-based chemotherapy in NSCLC patients. We used AllGloTM probe to assess genotyping and polymorphisms in 388 stage IIIB and IV NSCLC patients treated with platinum-based chemotherapy. MMS19L might be associated with the adverse events of chemotherapy in NSCLC, especially for all grade leucopenia P = 0.020, all grade jaundice P = 0.037 and all grade creatinine increasing P = 0.013. In terms of grade 3-4 adverse events, MMS19L was related with total grade 3-4 adverse events P = 0.024 and grade 3-4 thrombocytopenia P = 0.035, while RRM1 was related with total grade 3-4 adverse events P = 0.047 and grade 3-4 vomiting P = 0.046. ERCC5 was related with more infection P = 0.017. We found that some SNPs in NER pathway genes were correlated with toxicity treated with double chemotherapy in advanced NSCLC patients, especially for SNPs of MMS19L, RRM1 and ERCC5.



Autor: Ling Zhang , Guanghui Gao , Xuefei Li, Shengxiang Ren, Aiwu Li, Jianfang Xu, Jie Zhang, Caicun Zhou

Fuente: http://plos.srce.hr/



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