TRIP Database 2.0: A Manually Curated Information Hub for Accessing TRP Channel Interaction NetworkReportar como inadecuado




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Transient receptor potential TRP channels are a family of Ca2+-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP TRansient receptor potential channel-Interacting Protein Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions PPIs. However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 http:-www.trpchannel.org in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1 the PPI information found in the supplementary data of referred articles was curated; 2 the PPI summary matrix enables users to intuitively grasp overall PPI information; 3 the search capability has been expanded to retrieve information from ‘PubMed’ and ‘PIE the search’ a specialized search engine for PPI-related articles; and 4 the PPI data are available as sif files for network visualization and analysis using ‘Cytoscape’. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.



Autor: Young-Cheul Shin , Soo-Yong Shin , Jung Nyeo Chun, Hyeon Sung Cho, Jin Muk Lim, Hong-Gee Kim, Insuk So, Dongseop Kwon , Ju-Hong J

Fuente: http://plos.srce.hr/



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