The Role of VEGF and KDR Polymorphisms in Moyamoya Disease and Collateral RevascularizationReportar como inadecuado

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We conducted a case-control study to investigate whether vascular endothelial growth factor VEGF −2578, −1154, −634, and 936 and kinase insert domain containing receptor KDR −604, 1192, and 1719 polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease n = 107, mean age, 20.9±15.9 years; 66.4% female and 243 healthy control subjects mean age, 23.0±16.1 years; 56.8% female were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good collateral grade A or poor collateral grade B and C groups. The frequencies and distributions of four VEGF −2578, −1154, −634, and 936 and KDR −604, 1192, and 1719 polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF −2578, −1154, −634, and 936 or KDR −604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the −634CC genotype occurred less frequently in the pediatric moyamoya group p = 0.040 whereas the KDR −604C-1192A-1719T haplotype increased the risk of pediatric moyamoya p = 0.024. Patients with the CC genotype of VEGF −634 had better collateral vessel formation after surgery. Our results suggest that the VEGF −634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.

Autor: Young Seok Park, Young Joo Jeon, Hyun Seok Kim, Kyu Young Chae, Seung-Hun Oh, In Bo Han, Hyun Sook Kim, Won-Chan Kim, Ok-Joon Kim



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