Flare, Persistently Active Disease, and Serologically Active Clinically Quiescent Disease in Systemic Lupus Erythematosus: A 2-Year Follow-Up StudyReportar como inadecuado




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Objective

Several indices have been proposed to assess disease activity in patients with Systemic Lupus Erythematosus SLE. Recent studies have showed a prevalence of flare between 28–35.3%, persistently active disease PAD between 46%–52% and serologically active clinically quiescent SACQ disease ranging from 6 to 15%. Our goal was to evaluate the flare, PAD and SACQ rate incidence in a cohort of SLE patients over a 2-year follow-up.

Methods

We evaluated 394 SLE patients. Flare was defined as an increase in SLEDAI-2K score of ≥4 from the previous visit; PAD was defined as a SLEDAI-2K score of ≥4, on >2 consecutive visits; SACQ was defined as at least a 2-year period without clinical activity and with persistent serologic activity.

Results

Among the 95 patients eligible for the analysis in 2009, 7 7.3% had ≥1 flare episode, whereas 9 9.4% had PAD. Similarly, among the 118 patients selected for the analysis in 2010, 6 5% had ≥1 flare episode, whereas 16 13.5% had PAD. Only 1-45 patient 2.2% showed SACQ during the follow-up.

Conclusion

We showed a low incidence of flare, PAD and SACQ in Italian SLE patients compared with previous studies which could be partly explained by ethnic differences.



Autor: Fabrizio Conti, Fulvia Ceccarelli, Carlo Perricone , Francesca Miranda, Simona Truglia, Laura Massaro, Viviana Antonella Pacucci,

Fuente: http://plos.srce.hr/



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