Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-AnalysisReportar como inadecuado




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Objective

A great number of studies regarding the associations between IL-1B-511, IL-1B+3954 and IL-1RN VNTR polymorphisms within the IL-1gene cluster and coronary heart disease CHD have been published. However, results have been inconsistent. In this study, a meta-analysis was performed to investigate the associations.

Methods

Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios ORs with 95% confidence intervals CIs were calculated using random- or fixed- effect model.

Results

Thirteen studies 3,219 cases-2,445 controls for IL-1B-511 polymorphism, nine studies 1,828 cases-1,818 controls for IL-1B+3954 polymorphism and twelve studies 2,987 cases- 2,208 controls for IL-1RN VNTR polymorphism were included in this meta analysis. The results indicated that both IL-1B-511 and IL-1B+3954 polymorphisms were not associated with CHD risk IL-1B-511 T vs. C: OR = 0.98, 95%CI 0.87–1.09; IL-1B+3954 T vs. C: OR = 1.06, 95%CI 0.95–1.19. Similarly, there was no association between IL-1RN VNTR polymorphism and CHD risk *2 vs. L: OR = 1.00, 95%CI 0.85–1.17.

Conclusions

This meta-analysis suggested that there were no associations between IL-1 gene cluster polymorphisms and CHD.



Autor: Liang Zhou , Jianguang Cai, Gang Liu, Yuan Wei, Hui Tang

Fuente: http://plos.srce.hr/



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