Engineering Chitosan Using α, ω-Dicarboxylic Acids—An Approach to Improve the Mechanical Strength and Thermal StabilityReportar como inadecuado




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The current scenario in tissueengineering research demands materials of requisite properties, viz., high porosity, mechanical stability, thermal stability,biocompatibility and biodegradability for clinical applications. However,bringing these properties in single biomaterial is a challenging task, whichneeds intensive research on suitable cross-linking agents. In the presentstudy, 3D scaffold was prepared with above said properties using chitosan andoxalic O, malonic M, succinic S, glutaric G, adipic A, pimelic P,suberic SU, azelaic AZ and sebacic SE acid OMS- GAP-SAS individually as a noncovalent cross-linkers as well as the solvent for chitosan. Assessment on degreeof cross-linking, mechanical strength, FT-IR analysis, morphologicalobservation, thermal stability, binding interactions molecular docking, in vitro biocompatibility and itsefficacy as a wound dressing material were performed. Results revealed thedegree of cross-linking for OMSGAP-SAS engineered chitosan were in the rangebetween ≈55% - 65% and the biomaterial demonstratedthermal stability more than 300°C and also exhibited ≥3 - 4 fold increase in mechanical strength compared to chitosanalone. The bioinformatics studies evidently proved the chemistry behind the interaction of OMSGAP-SAS with chitosan.OMSGAP-SAS played dual role to develop the chitosan biomaterial with above saidproperties, thus matching the requirements needed for various applications.

KEYWORDS

Biomaterial; Chitosan; Cytocompatibility; Dicarboxylic Acid; Mechanical Property

Cite this paper

G. Sailakshmi, T. Mitra, S. Chatterjee and A. Gnanamani -Engineering Chitosan Using α, ω-Dicarboxylic Acids—An Approach to Improve the Mechanical Strength and Thermal Stability,- Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 2, 2013, pp. 151-164. doi: 10.4236-jbnb.2013.42021.





Autor: G. Sailakshmi, Tapas Mitra, Suvro Chatterjee, A. Gnanamani

Fuente: http://www.scirp.org/



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