Targeting Viral Antigens to CD11c on Dendritic Cells Induces Retrovirus-Specific T Cell ResponsesReportar como inadecuado




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Dendritic cells DC represent the most potent antigen presenting cells and induce efficient cytotoxic T lymphocyte CTL responses against viral infections. Targeting antigens Ag to receptors on DCs is a promising strategy to enhance antitumor and antiviral immune responses induced by DCs. Here, we investigated the potential of CD11c-specific single-chain fragments scFv fused to an immunodominant peptide of Friend retrovirus for induction of virus-specific T cell responses by DCs. In vitro CD11c-specific scFv selectively targeted viral antigens to DCs and thereby significantly improved the activation of virus-specific T cells. In vaccination experiments DCs loaded with viral Ag targeted to CD11c provided improved rejection of FV-derived tumors and efficiently primed virus-specific CTL responses after virus challenge. Since the induction of strong virus-specific T cell responses is critical in viral infections, CD11c targeted protein vaccines might provide means to enhance the cellular immune response to prophylactic or therapeutic levels.



Autor: Asim Ejaz, Christoph G. Ammann, Roland Werner, Georg Huber, Verena Oberhauser, Susanne Hörl, Simone Schimmer, Ulf Dittmer, Dorot

Fuente: http://plos.srce.hr/



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