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Uropathogenic Escherichia coli UPEC causes uncomplicatedurinary tract infection UTI depicts a prevalent and potentially uncompromisinginfectious disease. In this analysis, we explained the functions of an immunoproteomicsconcept to vaccine development that has been successfully employed to recognizevaccine targets in other pathogenic bacteria. Pyelonephritis strains E. coli CFT073 are used for outer membraneisolation mimics urinary tract environment in which iron limitation, osmotic stress,human urine, and exposure to uroepithelial cells are included. During experimentsof UTI, the antigens that induce the humoral immune response is to identified, two-dimensionalgel electrophoresis are employed for the isolation of outer membrane protein andprobed using pooled antisera from 20 CBA-J mice chronically infected with E. coli CFT073. 23 total outer membraneantigens, in which a unique iron compound receptor is included, are reacted withantisera and were identified by mass spectrometry. These antigens comprises ofproteins with known functions in UPEC pathogenesis such as, ChuA, IroN, IreA, Iha,IutA, and FliC. These all information and data elaborate that these factors areassociated with virulence during UTI are directed by antibody response. We alsorepresents that the genes encoding ChuA, IroN, hypothetical protein c2482, and IutAare significantly more prevalent among UPEC strains than among fecal-commensal E. coli isolates.Therefore we concluded that, the outer membraneantigens are identified in this study are conserved, could be reflectivepart for the UTI vaccine generated to induce protective immunity against UPEC infections.

KEYWORDS

Pyelonephritis; Outer Membrane Antigen; Iron Compound Receptors

Cite this paper

Bauer, H. , Shams, H. and Bauer, R. 2013 Vaccination against urinary tract infections caused by E. coli. Advances in Bioscience and Biotechnology, 4, 487-492. doi: 10.4236-abb.2013.43A064.





Autor: Hartwig Wilhelm Bauer, Hira Shams, Ricarda Michaela Bauer

Fuente: http://www.scirp.org/



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