Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by Helicobacter pyloriReportar como inadecuado

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Background and Objectives: Several recentreports have demonstrated a close linkage between idiopathic thrombocytopenic purpura ITP and Helicobacter pylori H. pylori infection in somepatient’s populations. However, the pathogenetic mechanisms of H. pylori-induced thrombocytopeniaremain obscure. Therefore, we investigated the prevalence of H. pylori infection pylori and performeda comparative analysis of a subset of H.pylori-infected patients group A with non-infected patients group Busing the standard statistical methods. Design and Methods: From December2001 to October 2002, we investigated the presence of gastric H. pylori infection in 30 adult ITPpatients and 19 patientswere treated with standard antibiotic therapy for H. pylori eradication amoxicillin and clarithromycin plus lansoprazole combination. We used thestandard statisticsto analyze the difference between group A and group B. Results: H. pylori eradication was achieved in 17-19 89.4% H.pylori-infectedpatients. An improvement of platelet count was observed in 14-19 patients73.6% who achieved the eradication. Five of these patients achieved CR twopatients were with the acute ITP and nine patients reached PR. The differencebetween the mean platelet count ± S.D. before and after H. pylori therapy was statisticallysignificant in patients with successful decontamination 65 ± 48 × 109-L vs. 200 ± 140 × 109-L; p = 0.018. Lymphocyte counts at thediagnosis of H. pylori infected caseswere significant higher than those of non-infected cases 1.58 ± 0.13 × 109

Autor: Naoki Takezako, Naohiro Sekiguchi, Akira Tanimura, Chiho Homma, Tateki Shikai, Yayoi Takezako, Noboru Yamagata, Akiyoshi Miwa



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