Progression of Platelet Counts in Treatment Naïve HIV-HCV Co-InfectionReport as inadecuate

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Background: Previous research has suggested an association between infection with hepatitisC virus HCV or with human immunodeficiency virus HIV and low plateletcounts. This studyestimates platelet count changes over time in HIV-HCV co-infected participantsand compares them with the changes in platelet count among HIV mono-infectedparticipants to test if HIV-HCV co-infection is associated with lower plateletcounts. Methods: This retrospective cohort study included all HIVtreatment naive patients from four sites in the Centers for AIDS ResearchNetwork of Integrated Clinical Systems CNICS cohort with platelet countmeasurements between 2002 and 2009. We conducted a mixed effects linearregression modeling the mean change in platelet count per year while adjustingfor age, sex, race, baseline CD4 cell count, and site. Index date was the firstplatelet count after 2002, and participants were censored upon initiation oftreatment for HIV or HCV. Results: There were 929 HIV-HCV co-infected and 3558 HIV mono-infected participants witha mean follow-up time of 1.2 years. HIV-HCV co-infected participants had onaverage a slighter lower platelet count at baseline 234,040 vs. 242,780-μL;p-value = 0.004, and a more rapid meanreduction per year 7230 vs. 3580-μL; p-value

Author: Jonathan E. Schelfhout, Danijela A. Stojanovic, Amy Houtchens, Heidi M. Crane, Edward R. Cachay, Elizabeth R. Brown, Sonia M. Nap



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