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Polycythemia vera PV ischaracterized by leukocytosis, thrombocytosis, and low meancapsular volume MCV. No specific hematological findings areobserved in patients with erythrocytosis of other origins. However, recombinanterythropoietin EPO increases the number of mononuclear cells in the peripheralblood. Therefore, we hematologically examined monocytes in patients witherythrocytosis. The medical records of 48 erythrocytosis patients hemoglobin: men, >18.5 g-dL; women, >16.5 g-dL collected between August 2005 and July 2012 were reviewed for age, gender, hematology, andserum erythropoietin level. Patients were divided into 3 groups: PV N = 17,reactive erythrocytosis RE, N = 25, and EPO-elevated erythrocytosis EPO-E, N= 6. We compared monocytes in the hemogram among the 3 groups and examined thecorrelation between hematological data and serum EPO level. The percentmonocytes in the hemogram were 3.4% ± 0.3%, 7.4% ± 0.4%, and 12.3% ± 1.1% forthe PV, RE, and EPO-E groups, respectively, which were significant p <0.05. Absolute monocyte counts in the EPO-E group 1.0 ± 0.1 × 109-Lwere significantly higher than those in the PV 0.6 ± 0.1 × 109-Land RE 0.5 ± 0.3 × 109-L groups. There were 2 12%, 0, and 350% patients with monocytosis >1.0 ′ 109-L in the PV, RE, and EPO-E groups, respectively.A significant correlation was observed between percent monocyte or absolutemonocyte count and serum EPO level. In conclusion, monocyte count in hemograms may be useful for diagnosing EPO-elevated erythrocytosis.


Erythropoietin; Monocyte; Erythrocytosis

Cite this paper

H. Fujita, A. Ohwada, N. Handa and S. Nishimura -Relative Monocytosis in Patients with Erythrocytosis,- Open Journal of Blood Diseases, Vol. 3 No. 1, 2013, pp. 21-24. doi: 10.4236-ojbd.2013.31005.

Autor: Hiroshi Fujita, Akira Ohwada, Naoko Handa, Shigeko Nishimura



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