Effect of Birth Year on Birth Weight and Obesity in Adulthood: Comparison between Subjects Born Prior to and during the Great Depression in IcelandReportar como inadecuado




Effect of Birth Year on Birth Weight and Obesity in Adulthood: Comparison between Subjects Born Prior to and during the Great Depression in Iceland - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Many epidemiological studies have linked small size at birth to adverse adult health outcomes but the relative influence of environmental exposures is less well established.

Methods

The authors investigated the impact of prenatal environmental exposure by comparing 2750 participants born before 1925–1929 and during 1930–1934 the Great Depression in Reykjavik, Iceland. Calendar year served as proxy for environmental effects. Anthropometric measurements at birth and school-age 8–13 years were collected from national registries. Participants were medically examined as adults 33–65 years.

Results

Mean birth weight, adjusted for maternal age and parity, decreased by 97 g 95% confidence interval CI: 39, 156 for men and 70 g 95% CI: 11, 129 for women from 1925 to 1934; growth at school-age was significantly reduced for participants growing during the Depression. As adults, women prenatally exposed to the Depression had higher body mass index Δ0.6 kg-m2, 95% CI: 0.2, 1.1, higher fasting blood glucose levels Δ0.16 mmol-L, 95% CI: 0.07, 0.23 and greater odds of being obese 1.43 95% CI: 1.01, 2.02 compared to unexposed counterparts. Non-significant associations were observed in men.

Conclusion

Reduction in birth weight due to rapid shifts in the economic environment appears to have a modest but significant association with later obesity for women while male offspring appear to be less affected by these conditions.



Autor: Cindy Mari Imai , Thorhallur Ingi Halldorsson, Ingibjorg Gunnarsdottir, Vilmundur Gudnason, Thor Aspelund, Gudmundur Jonsson, Bry

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados