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sentsa syndrome, and there is clinical and pathobiological heterogeneity. Many genesare reported to be associated with asthma, and may be involved in the diseaseheterogeneity. Diverse cells, such as T helper 1 Th1-cells, Th2-cells,Th17-cells, airway epithelial cells, and innate and adaptive immunityassociated cells, contribute to the pathobiology of asthma independently ofeach other or they can also coexist and interact. Although, generally, Th2immunity is important in most asthma endotypes, non- Th2-driven inflammationtends to be difficult to manage. Recently, increased attention has been focusedon severe asthma and glucocorticoid GC-resistant GC-R asthma, in whichdiverse inflammatory processes may be involved. Treatment approaches shouldtake into account pathological differences.

KEYWORDS

Asthma Phenotype; Genome-Wide Association Study GWAS; Glucocorticoid GC-Resistant GC-R Asthma; Severe Asthma

Cite this paper

Matsumura, Y. 2013 Clinical and pathobiological heterogeneity of asthma—Mechanisms of severe and glucocorticoid-resistant asthma. Health, 5, 344-350. doi: 10.4236-health.2013.52A046.





Autor: Yasuhiro Matsumura

Fuente: http://www.scirp.org/



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