The airway epithelium dysfunction in the pathogenesis of asthma: The evidenceReportar como inadecuado




The airway epithelium dysfunction in the pathogenesis of asthma: The evidence - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Asthmais traditionally defined as a chronic, multisystem, multicellular diseasecharacterized by bronchial hyper-responsiveness BHR and lung inflammation. Inthis illness is particularly involving the airway epithelium as the place wherethe inflammation begins, develops and often returns through airway remodelling.In specific way there is also an evolving awareness of the active participationof structural elements, such as the airway epithelium, airway smooth muscle,and endothelium, in this process. The airway inflammation and remodellingtogether likely explain the clinical manifestations of asthma that is demonstratedby complicated respiratory manifestations in which wheeze occurring secondaryto bronchoconstriction in the setting of airway hyper-responsiveness and mucoushypersecretion. This is confirmed by also the histopathological analyses ofbronchial biopsies from asthmatic subjects. For this reason is very importantto understand the physiological role of the airway epithelium and their changesduring the exacerbation of disease.

KEYWORDS

Airway Epithelium; Dysfunction; Asthma; Evidence

Cite this paper

Leonardi, S. , Coco, A. , Del Giudice, M. , Marseglia, G. and La Rosa, M. 2013 The airway epithelium dysfunction in the pathogenesis of asthma: The evidence. Health, 5, 331-338. doi: 10.4236-health.2013.52A044.





Autor: Salvatore Leonardi, Alfina Coco, Michele Miraglia Del Giudice, Gianluigi L. Marseglia, Mario La Rosa

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados