Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-AnalysisReportar como inadecuado

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The association between body mass index BMI and mortality in patients suffering from chronic obstructive pulmonary disease COPD has been a subject of interest for decades. However, the evidence is inadequate to draw robust conclusions because some studies were generally small or with a short follow-up.


We carried out a search in MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE database for relevant studies. Relative risks RRs with 95% confidence interval CI were calculated to assess the association between BMI and mortality in patients with COPD. In addition, a baseline risk-adjusted analysis was performed to investigate the strength of this association.


22 studies comprising 21,150 participants were included in this analysis. Compared with patients having a normal BMI, underweight individuals were associated with higher mortality RR  = 1.34, 95% CI  = 1.01–1.78, whereas overweight RR  = 0.47, 95% CI  = 0.33–0.68 and obese RR  = 0.59, 95% CI  = 0.38–0.91 patients were associated with lower mortality. We further performed a baseline risk-adjusted analysis and obtained statistically similar results.


Our study showed that for patients with COPD being overweight or obese had a protective effect against mortality. However, the relationship between BMI and mortality in different classes of obesity needed further clarification in well-designed clinical studies.

Autor: Chao Cao, Ran Wang, Jianmiao Wang, Hansvin Bunjhoo, Yongjian Xu, Weining Xiong



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