RU486 Reversal of Cortisol Repression of 1,25-Dihydroxyvitamin D3 Induction of the Human Osteocalcin PromoterReportar como inadecuado




RU486 Reversal of Cortisol Repression of 1,25-Dihydroxyvitamin D3 Induction of the Human Osteocalcin Promoter - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

In conditions of corticosteroid excess, such as Cushing’s syndrome, a reduction in serum osteocalcin is observed and bone loss occurs. The human osteocalcin gene is induced by 1,25-dihydroxyvitamin D3 derivatives and repressed by glucocorticoids. In this paper we show that cortisol, a natural glucocorticoid, represses both basal and vitamin D induced activity of the human osteocalcin promoter. Furthermore, we address the specific question as to whether the anti-progestin anti-glucocorticoid RU486 is able to antagonize the inhibitory effect of cortisol on osteocalcin gene expression. We show that RU486 has agonist activity alone, in that it is able to repress the basal promoter activity of the osteocalcin gene and antagonist activity, reversing incompletely the cortisol mediated repression of 1,25-dihydroxyvitamin D3 induction.

KEYWORDS

RU486; Osteocalcin; Vitamin D; Glucocorticoid

Cite this paper

N. A. Morrison -RU486 Reversal of Cortisol Repression of 1,25-Dihydroxyvitamin D3 Induction of the Human Osteocalcin Promoter,- Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 1, 2013, pp. 55-62. doi: 10.4236-ojemd.2013.31009.





Autor: Nigel A. Morrison

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados