Active Chronic Sarcoidosis is Characterized by Increased Transitional Blood B Cells, Increased IL-10-Producing Regulatory B Cells and High BAFF LevelsReportar como inadecuado




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Background

Sarcoidosis is a multisystemic disease of unknown etiology characterized by a disproportionate Th1 granulomatous immune response in the organs involved. Plasmatic hypergammaglobulinemia and B cell accumulation in granulomatous lesions suggest the possible role of humoral immune responses in the pathogenesis of sarcoidosis. The purpose of this study is to describe B cell peripheral compartment in sarcoidosis.

Methodology-Principal Findings

We analyzed blood B cell subsets and BAFF levels in 33 patients with chronic sarcoidosis active sarcoidosis n = 18; inactive sarcoidosis n = 15 and 18 healthy donors. Active chronic sarcoidosis patients had significantly less circulating memory B cells p<0.01, more transitional p<0.01 and increased numbers of IL-10-producing regulatory B cells p<0.05 compared with healthy donors and patients with inactive sarcoidosis. BAFF serum levels were significantly higher in patients with active sarcoidosis p<0.01 versus healthy donors and inactive sarcoidosis patients and strongly correlated with serum hypergammaglobulinemia r = 0.53, p<0.01 and angiotensin converting enzyme levels r = 0.61, p = <0.01.

Conclusions-Significance

These data show that there is an altered B cell homeostasis in active sarcoidosis and suggest BAFF antagonist drugs as potential new treatments of this disease.



Autor: Anne Saussine, Abdellatif Tazi, Séverine Feuillet, Michel Rybojad, Caroline Juillard, Anne Bergeron, Valérie Dessirier, Fatiha

Fuente: http://plos.srce.hr/



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