Ethnic-Specific Differences in Vitamin D Status Is Associated with AdiposityReportar como inadecuado




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Background

Low circulating 25 hydroxyvitamin D 25OHD concentrations are common in obesity BMI ≥30 kg-m2 and a negative relationship with body fat distribution has recently been reported. Ethnic-specific differences in body fat distribution have been described with South Asians are reported to have greater visceral adipose tissue VAT, which could influence circulating 25OHD concentrations. The objective of this study is to investigate the relationship between plasma 25OHD, adiposity, and body fat distribution in Europeans and South Asians.

Methods-Principal Findings

187 Europeans and 192 South Asians were assessed for demographics, anthropometrics, and plasma 25OHD concentrations. Subcutaneous adipose tissue SAT and VAT were quantified by CT scan, and percent body fat by DEXA. Data were assessed by general linear models. South Asians had lower P<0.001 plasma 25OHD concentrations and higher VAT P = 0.04 than Europeans. Plasma 25OHD concentrations were negatively P<0.05 associated with BMI, waist circumference, percent body fat, total adipose tissue, VAT, and SAT in unadjusted models and negatively P<0.05 associated with VAT, SAT, and percent body fat after adjusting for BMI, ethnicity, age, and season of blood collection in males and females. When percent body fat, VAT, and SAT were included in the same model, only VAT remained negatively P<0.05 associated with plasma 25OHD concentrations. Ethnicity remained significant in all models P<0.001.

Conclusion

Compared to other adipose tissue compartments, VAT may have a distinct role in determining plasma 25OHD concentrations, which may account for the lower levels in South Asians.



Autor: Dian C. Sulistyoningrum, Timothy J. Green, Scott A. Lear, Angela M. Devlin

Fuente: http://plos.srce.hr/



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