Subthalamic Nucleus Deep Brain Stimulation Impacts Language in Early Parkinsons DiseaseReportar como inadecuado

Subthalamic Nucleus Deep Brain Stimulation Impacts Language in Early Parkinsons Disease - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Although deep brain stimulation DBS of the basal ganglia improves motor outcomes in Parkinson-s disease PD, its effects on cognition, including language, remain unclear. This study examined the impact of subthalamic nucleus STN DBS on two fundamental capacities of language, grammatical and lexical functions. These functions were tested with the production of regular and irregular past-tenses, which contrast aspects of grammatical regulars and lexical irregulars processing while controlling for multiple potentially confounding factors. Aspects of the motor system were tested by contrasting the naming of manipulated motor and non-manipulated non-motor objects. Performance was compared between healthy controls and early-stage PD patients treated with either DBS-medications or medications alone. Patients were assessed on and off treatment, with controls following a parallel testing schedule. STN-DBS improved naming of manipulated motor but not non-manipulated non-motor objects, as compared to both controls and patients with just medications, who did not differ from each other across assessment sessions. In contrast, STN-DBS led to worse performance at regulars grammar but not irregulars lexicon, as compared to the other two subject groups, who again did not differ. The results suggest that STN-DBS negatively impacts language in early PD, but may be specific in depressing aspects of grammatical and not lexical processing. The finding that STN-DBS affects both motor and grammar but not lexical functions strengthens the view that both depend on basal ganglia circuitry, although the mechanisms for its differential impact on the two improved motor, impaired grammar remain to be elucidated.

Autor: Lara Phillips , Kaitlyn A. Litcofsky, Michael Pelster, Matthew Gelfand, Michael T. Ullman , P. David Charles



Documentos relacionados