Glutathione S-Transferase M1 Gene Polymorphism and Laryngeal Cancer Risk: A Meta-AnalysisReportar como inadecuado




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Background and Objectives

Studies investigating the association between glutathione S-transferase M1 GSTM1 gene polymorphism and laryngeal cancer risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible associations of GSTM1 gene polymorphism with laryngeal cancer risk.

Methods

The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until May 2011 and selected on the basis of the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize association of GSTM1 polymorphism with laryngeal cancer susceptibility.

Results

Seventeen studies were included in the present meta-analysis 2,180 cases and 2,868 controls. The combined results based on all studies showed that GSTM1 null genotype was associated with increased laryngeal cancer risk OR = 1.17, 95% CI = 1.04∼1.31. When stratifying for race, GSTM1 null genotype exhibited increased laryngeal cancer risk in Caucasians OR = 1.15, 95% CI = 1.01∼1.31, while no significant association was detected in Asians OR = 1.25, 95% CI = 0.80∼1.96. In the subgroup analysis based on source of controls, significant associations were observed in the population-based studies OR = 1.15, 95% CI = 1.01∼1.31 yet not in the hospital-based studies OR = 1.25, 95% CI = 0.93∼1.67. Furthermore, in the subgroup analysis based on sample size, significant associations were also found in studies with at least 50 cases and 50 controls OR = 1.15, 95% CI = 1.02∼1.30 but not in studies with fewer than 50 cases or 50 controls OR = 1.46, 95% CI = 0.87∼2.46.

Conclusions

This meta-analysis supported that the GSTM1 gene polymorphism was associated with laryngeal cancer, particularly in Caucasians, and these associations varied in different subgroup, which indicated that population-based study with larger sample size was more appropriate in design of future study.



Autor: Xin-Jiang Ying , Pin Dong , Bin Shen, Cheng-Zhi Xu, Hong-Ming Xu, Shu-Wei Zhao

Fuente: http://plos.srce.hr/



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