Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican PopulationReportar como inadecuado


Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population


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Citation

Bare, Lance A., Edward A. Ruiz-Narvaéz, Carmen H. Tong, Andre R. Arellano, Charles M. Rowland, Joseph J. Catanese, Frank M. Sacks, James J. Devlin, Hannia Campos. -Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population- PLoS ONE 59: e13081. 2010

Abstract

BACKGROUND AND METHODOLOGY. The 719Arg allele of KIF6 rs20455 was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction MI in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases 1,987 had survived a first MI; controls 2,147 had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations. PRINCIPAL FINDINGS. Compared with the reference Trp-Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture OR=1.12; 95%CI, 0.98-1.28. Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 95% confidence interval, 1.01-1.34, but this association would not be significant after a multiple testing correction. CONCLUSIONS-SIGNIFICANCE. We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.Rights

Bare et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Slone Epidemiology Center Papers -



Autor: Bare, Lance A. - Ruiz-Narvaéz, Edward A. - Tong, Carmen H. - Arellano, Andre R. - Rowland, Charles M. - Catanese, Joseph J. - Sa

Fuente: https://open.bu.edu/







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