Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional StudyReport as inadecuate




Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional Study - Download this document for free, or read online. Document in PDF available to download.

Background

The worldwide burden of diabetes in 2030 is projected around 552 million. Diabetes leads to higher risk for cardiovascular diseases CVD. Altered cardiac autonomic function CAF measured by heart rate variability HRV is observed in early stages of diabetes but the relationship between impaired fasting glucose IFG and HRV is still debatable. The aim of the study was to evaluate the association between CAF, oxidative stress, insulin resistance IR, and inflammatory response in IFG subjects.

Subjects and Methods

Cross-sectional blinded study. Volunteers recruited from health awareness camps underwent CAF and biochemical tests. Based on fasting plasma glucose FPG participants n = 123 were divided into two groups, normal fasting glucose n = 76 and IFG n = 47. The comparison of parameters between the groups was carried out using student t test and Mann-Whitney U test for parametric and non-parametric data respectively. The correlation between the parameters was analyzed by Spearman’s rank correlation using SPSS 13.0.

Results

The resting cardiovagal modulation parameters, heart rate response to forced timed breathing, and orthostatic stress were reduced in IFG subjects. Fasting plasma lipid profile, coronary atherogenic lipid risk factors, IR, thiobarbituric acid reactive substance TBARS, high sensitive C-reactive protein, and tumor necrosis factor alpha were increased and total antioxidant capacity TAC was decreased significantly in IFG group but no significant alteration was observed in high-density lipoprotein HDL-c. Cardiovagal modulation parameters were negatively correlated with triglycerides, FPG, insulin, IR, TBARS, and inflammatory markers and positively with TAC.

Conclusion

There is a continuous interplay between the altered CAF, hyperinsulinemia, IR, oxidative stress parameters, inflammatory response, and IFG in which one factor perpetuates another leading to the progression of disease.



Author: Ramkumar Thiyagarajan , Senthil Kumar Subramanian, Nishanth Sampath, Madanmohan Trakroo, Pravati Pal, Zachariah Bobby, Sankar Pan

Source: http://plos.srce.hr/



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