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Dermal neocollagenesis is often assumed to be the main reason of visible skin improvement after different non-invasive and minimal invasive aesthetic treatments. However, the very slow dynamics of the mature collagen remodelling in the extra cellular matrix ECM of dermis, with a half-life time of 15 years, renders every observable upregulation of collagen production insufficient to replace a significant part of the matrix during the short time in which it is claimed skin improvement takes place.


Neocollagenesis; Aesthetic Treatments; Procollagen; Mature Collagen; Turnover

Cite this paper

I. Kruglikov -Neocollagenesis in Non-Invasive Aesthetic Treatments,- Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 3 No. 1A, 2013, pp. 1-5. doi: 10.4236-jcdsa.2013.31A001.

Autor: Ilja L. Kruglikov



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