Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetesReportar como inadecuado




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Obesity,especially at mid-life, is a major risk factor for atherosclerosis, insulinresistance and the metabolic syndrome, which in turn contribute to coronaryartery disease CAD, Type 2 diabetes and Alzheimer’s disease AD. The rise inoverweight and obesity in all societies is prompting intense research into thecauses and effects of the condition. Obesity disrupts many body systemsincluding glucose and lipid metabolism, circadian rhythms and liver function.It also causes or increases inflammation and oxidative stress. Within cells,the endoplasmic reticulum ER appears to be particularly susceptible to suchmetabolic disruption. Sirtuin 1 Sirt1 and leptin have received attentionrecently as they are central regulatory factors for the body’s metabolicpathways which interact at particular levels, for example lipid and Abetametabolism. This mini-review discusses recent findings concerning obesity,lipid metabolism and the role of Sirtuin 1 and how all influence the ER. Agreater understanding of obesity and its effects on metabolic control systemsof the body are required, to develop pharmacological, dietary and lifestylechanges that will reduce the incidence of CAD, Type 2 diabetes and AD.



KEYWORDS

Obesity; Sirtuin 1; Alzheimer’s Disease; Cardiovascular Disease; Diabetes

Cite this paper

Martins, I. , Wilson, A. , Lim, W. , Laws, S. , Fuller, S. and Martins, R. 2012 Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes. Health, 4, 1448-1456. doi: 10.4236-health.2012.412A209.





Autor: Ian James Martins, Andrea. C. Wilson, Wei Ling Florence Lim, Simon. M. Laws, Stephanie. J. Fuller, Ralph Nigel Martins

Fuente: http://www.scirp.org/



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