5-HT2A Receptor Activation Normalizes Exaggerated Fear Behavior in p-Chlorophenylalanine PCPA-Treated RatsReportar como inadecuado




5-HT2A Receptor Activation Normalizes Exaggerated Fear Behavior in p-Chlorophenylalanine PCPA-Treated Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Deficits in serotonin 5-hydroxytryptamine, 5-HT neurotransmission are implicated in abnormal emotional behaviors such as aggression, anxiety, and depression. However, the specific 5-HT receptor mechanisms involved are not well understood. The role of 5-HT2 receptors in fear potentiated startle, FPS was examined in rats chronically treated with pchlorophenylalanine PCPA to reduce brain 5-HT. PCPA-treated rats show an enhanced magnitude of FPS. Systemic administration of the 5-HT2 receptor agonist ±-2,5-Dimethoxy-4-iodoamphetamine hydrochloride DOI reduced FPS in both PCPA-treated and saline SAL-treated control animals, normalizing the exaggerated fear response in PCPA-treated rats. In both SAL- and PCPA-treated animals, the DOI-induced reduction of learned fear was reversed by the 5-HT2 antagonist ketanserin, but not by the 5-HT2B-2C antagonist SB 206553. Together, these findings suggest 5-HT2A receptors are critical regulators of learned fear, and that 5-HT2A receptors may be an important pharmacological target to normalize exaggerated learned fear resulting from chronic 5-HT-ergic disruption.

KEYWORDS

Fear Conditioning; Startle Reflex; 5-HT2; DOI; Ketanserin; SB 206553

Cite this paper

C. Hughes, L. Tran and N. Keele -5-HT2A Receptor Activation Normalizes Exaggerated Fear Behavior in p-Chlorophenylalanine PCPA-Treated Rats,- Journal of Behavioral and Brain Science, Vol. 2 No. 4, 2012, pp. 454-462. doi: 10.4236-jbbs.2012.24053.





Autor: Cathryn R. Hughes, Lee Tran, N. Bradley Keele

Fuente: http://www.scirp.org/



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