Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lensReportar como inadecuado




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To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase AR activity in rat lenses. Of these, the ethyl acetate EtOAc fraction exhibited a unique AR inhibitory activity IC50 value, 0.11 μg-mL. Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity IC50 value, 4.03 μM. The content of apigenin was measured in B. balsamifera 0.47 mg-g by HPLC-UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.

KEYWORDS

Blumea balsamifera; Apigenin; Aldose Reductase Inhibition; HPLC

Cite this paper

D. Lee, S. Mok, C. Choi, E. Cho, H. Kim and S. Lee -Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens,- Journal of Agricultural Chemistry and Environment, Vol. 1 No. 1, 2012, pp. 28-33. doi: 10.4236-jacen.2012.11005.





Autor: Dong Gu Lee, So-Youn Mok, Changsun Choi, Eun Ju Cho, Hyun Young Kim, Sanghyun Lee

Fuente: http://www.scirp.org/



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