The -2518A-G Polymorphism in the MCP-1 Gene and Tuberculosis Risk: A Meta-AnalysisReportar como inadecuado




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Background

The -2518A-G polymorphism in the monocyte chemoattractant protein-1 MCP-1 gene has been implicated in the susceptibility to tuberculosis TB, but the results are not conclusive. The aim of this study is to investigate the association between the -2518A-G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis.

Methods

We searched Pubmed, Embase, CNKI and Wanfang databases, covering all studies until April 29th, 2011. Statistical analyses were performed using the Revman4.2 and STATA10.0 software.

Results

A total of 5341 cases and 6075 controls in 13 case-control studies were included in the meta-analysis. The results indicated that the GG homozygote carriers had a 67% increased risk of TB compared with the A allele carriers GG vs. GA+AA: OR = 1.67, 95%CI = 1.25–2.23, P = 0.0006. In the subgroup analysis by ethnicity, significant elevated risks were found in Asians and Latinos, but not in Africans GG vs. GA+AA: OR = 1.79, 95%CI = 1.19–2.70 and P = 0.005 for Asians; OR = 2.15, 95%CI = 1.32–3.51 and P = 0.002 for Latinos; OR = 1.28, 95%CI = 0.45–3.64 and P = 0.65 for Africans.

Conclusion

This meta-analysis suggested that the -2518A-G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans.



Autor: Yonggang Zhang, Jie Zhang, Lingjun Zeng, Honglang Huang, Min Yang, Xiaowei Fu, Can Tian, Zhangpeng Xiang, Jin Huang , Hong Fan

Fuente: http://plos.srce.hr/



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