The Genome of Ganderma lucidum Provide Insights into Triterpense Biosynthesis and Wood DegradationReport as inadecuate

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Ganoderma lucidum Reishi or Ling Zhi is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries. It is also a fungus with strong wood degradation ability with potential in bioenergy production. However, genes, pathways and mechanisms of these functions are still unknown.

Methodology-Principal Findings

The genome of G. lucidum was sequenced and assembled into a 39.9 megabases Mb draft genome, which encoded 12,080 protein-coding genes and ∼83% of them were similar to public sequences. We performed comprehensive annotation for G. lucidum genes and made comparisons with genes in other fungi genomes. Genes in the biosynthesis of the main G. lucidum active ingredients, ganoderic acids GAs, were characterized. Among the GAs synthases, we identified a fusion gene, the N and C terminal of which are homologous to two different enzymes. Moreover, the fusion gene was only found in basidiomycetes. As a white rot fungus with wood degradation ability, abundant carbohydrate-active enzymes and ligninolytic enzymes were identified in the G. lucidum genome and were compared with other fungi.


The genome sequence and well annotation of G. lucidum will provide new insights in function analyses including its medicinal mechanism. The characterization of genes in the triterpene biosynthesis and wood degradation will facilitate bio-engineering research in the production of its active ingredients and bioenergy.

Author: Dongbo Liu , Jing Gong , Wenkui Dai , Xincong Kang , Zhuo Huang, Hong-Mei Zhang, Wei Liu, Le Liu, Junping Ma, Zhilan Xia, Yuxin C



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