Predictors of Nonalcoholic Steatohepatitis in Patients with Elevated Alanine Aminotransferase ActivityReportar como inadecuado

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Collegium antropologicum, Vol.34 supplement 1 No.1 March 2010. -

Incidence of obesity and hepatic steatosis is increasing worldwide. Almost one quarter of western countries population suffer from non alcoholic fatty liver disease NAFLD. The aim of this study was to investigate the frequency and predictors of nonalcoholic steatohepatitis NASH in patients with unexplained alanine aminotransferase activity elevation ALT, and therefore avoid unnecessary biopsies in cases of simple steatosis. Earlier studies provided different results and have not answered the question how to distinguish NASH from simple steatosis. Ultrasound US, computed tomography CT and magnetic resonance MRI can detect steatosis with great sensitivity level, but not NASH. This study included 50 patients 18 women and 32 men with mean age 43±9 years, and with defined selected biochemical, anthropometric and hormone biomarkers. The average BMI was 27.1±3.81 kg-m2, insulin resistance HOMA IR 3.89± 3.81. All patients underwent liver biopsy and NASH was staged by NASH activity score NAS from 1 to 8. Results are compared to pathohistological finding as relevant method. The results show that 90% of patients n=45 had NAFLD minimal stage at least, and 15 30% had nonalcoholic steatohepatitis NASH. High triglyceride, low HDL and high ferritin serum levels correspond with NASH. As in earlier studies, insulin resistance as basic mechanism of NAFLD and NASH was confirmed.

fatty liver; steatohepatitis; metabolic syndrome; insulin resistance

Autor: Željko Puljiz - ; Department of Gastroenterology, University Hospital Center Split, Split, Croatia Davor Štimac - ; Department



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