Expression of Bone Morphogenetic Protein-7, Its Receptors and Smad1-5-8 in Normal Human Kidney and Renal Cell CancerReportar como inadecuado




Expression of Bone Morphogenetic Protein-7, Its Receptors and Smad1-5-8 in Normal Human Kidney and Renal Cell Cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Collegium antropologicum, Vol.34 supplement 2 No.2 April 2010. -

Bone morphogenetic proteins BMPs are cytokines which are important for kidney homeostasis but also have role in the some renal diseases and renal cell carcinoma RCC1–5. In the last three decades incidence of RCC was constantly increased and the role of different molecular biomarkers in RCC is explored1. We analyzed expression of BMP-7, their receptors BMPR-IA, BMPR-IB, BMPR-II and proteins of their signaling pathway pSmad1-5-8 in sixteen renal cancer samples and paired normal tissue. Tissue samples were analyzed by immunohistochemistry and Western blot. BMP-7, BMP receptors and pSmad1-5-8 were expressed in all structures of normal kidney but dominantly in the proximal tubular cells. In the cancer samples their expression was also noticed. Comparison of BMPs between different tissue showed increased expression of BMPR-IB and pSmad 1-5-8 and decreased expression of BMP-7 and BMPR-II in RCC compared to normal kidney. BMPR-IA was detected with immunohistochemistry but with Western blot attenuated signal was presented. BMP-7, BMP receptors and pSmad1-5-8 were showed in normal kidney and RCC. Detected alterations of BMP-7, BMP receptors and pSmad expression in RCC suggested their possible role in tumorigenesis of kidney cancer.

kidney; bone morphogenetic proteins; renal cell carcinoma; epidemiology; pathology



Autor: Dean Markić - ; Department of Urology, University Hospital of Rijeka, Rijeka, Croatia Tanja Ćelić - ; Department of Anatomy, S

Fuente: http://hrcak.srce.hr/



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