IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus InfectionReportar como inadecuado




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Interferon-inducible transmembrane IFITM proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus DENV. DENV infects cells directly or via antibody-dependent enhancement ADE in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.



Autor: Ying Kai Chan , I-Chueh Huang, Michael Farzan

Fuente: http://plos.srce.hr/



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