Comparative Analysis of Gene Content Evolution in Phytoplasmas and MycoplasmasReportar como inadecuado




Comparative Analysis of Gene Content Evolution in Phytoplasmas and Mycoplasmas - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Phytoplasmas and mycoplasmas are two groups of important pathogens in the bacterial class Mollicutes. Because of their economical and clinical importance, these obligate pathogens have attracted much research attention. However, difficulties involved in the empirical study of these bacteria, particularly the fact that phytoplasmas have not yet been successfully cultivated outside of their hosts despite decades of attempts, have greatly hampered research progress. With the rapid advancements in genome sequencing, comparative genome analysis provides a new approach to facilitate our understanding of these bacteria. In this study, our main focus is to investigate the evolution of gene content in phytoplasmas, mycoplasmas, and their common ancestor. By using a phylogenetic framework for comparative analysis of 12 complete genome sequences, we characterized the putative gains and losses of genes in these obligate parasites. Our results demonstrated that the degradation of metabolic capacities in these bacteria has occurred predominantly in the common ancestor of Mollicutes, prior to the evolutionary split of phytoplasmas and mycoplasmas. Furthermore, we identified a list of genes that are acquired by the common ancestor of phytoplasmas and are conserved across all strains with complete genome sequences available. These genes include several putative effectors for the interactions with hosts and may be good candidates for future functional characterization.



Autor: Ling-Ling Chen , Wan-Chia Chung , Chan-Pin Lin, Chih-Horng Kuo

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados