Association Analysis of IL-17A and IL-17F Polymorphisms in Chinese Han Women with Breast CancerReportar como inadecuado

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Research into the etiology of breast cancer has recently focused on the role of the immunity and inflammation. The proinflammatory cytokines IL-17A and IL-17F can mediate inflammation and cancer. To evaluate the influences of IL-17A and IL-17F gene polymorphisms on the risk of sporadic breast cancer, a case-control study was conducted in Chinese Han women.

Methodology and Principal Findings

We genotyped three single-nucleotide polymorphisms SNPs in IL-17A rs2275913, rs3819025 and rs3748067 and five SNPs in IL-17F rs7771511, rs9382084, rs12203582, rs1266828 and rs763780 to determine the haplotypes in 491 women with breast cancer and 502 healthy individuals. The genotypes were determined using the SNaPshot technique. The differences in the genotypic distribution between breast cancer patients and healthy controls were analyzed with the Chi-square test for trends. For rs2275913 in IL-17A, the frequency of the AA genotype was higher in patients than controls P = 0.0016. The clinical features analysis demonstrated significant associations between IL-17 SNPs and tumor protein 53 P53, progesterone receptor PR, human epidermal growth factor receptor 2 Her-2 and triple-negative ER-PR-Her-2- status. In addition, the haplotype analysis indicated that the frequency of the haplotype Ars2275913Grs3819025Grs3748067, located in the IL-17A linkage disequilibrium LD block, was higher in patients than in controls P = 0.0471 after correction for multiple testing.

Conclusions and Significance

Our results suggested that SNPs in IL-17A but not IL-17F were associated with the risk of breast cancer. Both IL-17A and IL-17F gene polymorphisms may provide valuable information for predicting the prognosis of breast cancer in Chinese women.

Autor: Lihong Wang , Yongdong Jiang , Youxue Zhang, Yuwen Wang, Sunhui Huang, Zhihua Wang, Baoling Tian, Yue Yang, Wei Jiang , Da Pang



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