Validation of a Dutch Risk Score Predicting Poor Outcome in Adults with Bacterial Meningitis in Vietnam and MalawiReportar como inadecuado




Validation of a Dutch Risk Score Predicting Poor Outcome in Adults with Bacterial Meningitis in Vietnam and Malawi - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

We have previously developed and validated a prognostic model to predict the risk for unfavorable outcome in Dutch adults with bacterial meningitis. The aim of the current study was to validate this model in adults with bacterial meningitis from two developing countries, Vietnam and Malawi. Demographic and clinical characteristics of Vietnamese n = 426, Malawian patients n = 465 differed substantially from those of Dutch patients n = 696. The Dutch model underestimated the risk of poor outcome in both Malawi and Vietnam. The discrimination of the original model c-statistic c 0.84; 95% confidence interval 0.81 to 0.86 fell considerably when re-estimated in the Vietnam cohort c = 0.70 or in the Malawian cohort c = 0.68. Our validation study shows that new prognostic models have to be developed for these countries in a sufficiently large series of unselected patients.



Autor: Ewout S. Schut, Matthijs C. Brouwer, Matthew Scarborough, Nguyen Thi Hoang Mai, Guy E. Thwaites, Jeremy J. Farrar, Johannes B. Re

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados