Longer Leukocyte Telomere Length Is Associated with Smaller Hippocampal Volume among Non-Demented APOE ε3-ε3 SubjectsReport as inadecuate




Longer Leukocyte Telomere Length Is Associated with Smaller Hippocampal Volume among Non-Demented APOE ε3-ε3 Subjects - Download this document for free, or read online. Document in PDF available to download.

Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects 29 ε3-ε3 carriers; 28 ε4 carriers aged 49–79 yr. Leukocyte telomere length correlated inversely with left rs = −0.465; p = 0.011, right rs = −0.414; p = 0.025, and total hippocampus volume rs = −0.519; p = 0.004 among APOE ε3-ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3-ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3-ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.



Author: Mikael Wikgren , Thomas Karlsson, Johanna Lind, Therese Nilbrink, Johan Hultdin, Kristel Sleegers, Christine Van Broeckhoven, Gö

Source: http://plos.srce.hr/



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