Lymphomatoid Granulomatosis in a 23-year-old Man – Cytological and Histological Typing and Rapid Response to Steroid and Cyclophosphamide Combination TherapyReportar como inadecuado




Lymphomatoid Granulomatosis in a 23-year-old Man – Cytological and Histological Typing and Rapid Response to Steroid and Cyclophosphamide Combination Therapy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Collegium antropologicum, Vol.34 No.1 March 2010. -

Lymphomatoid granulomatosis LG is currently called as extranodal angiocentric and angiodestructive immunoproliferative disorder with various degrees of histological differentiation and disease severity. Histological grading and clinical manifestations are due to number of atypical large EBV+ B-lymphatic cells. We report the case of a 23-year-old man clinically presented with fever, sweating, and physical intolerance, and bilateral pulmonary infiltrates of nodular type and destructive changes on the chest X-ray, previously treated with antituberculotics for 1.5 month. As the disease showed progression, diagnostic procedures extended to transbronchial lung biopsy and percutaneous fine needle aspiration with cytological and histological analysis of collected specimens, all being not conclusive enough. LG was confirmed by open lung biopsy, followed by induction of corticosteroids and cyclophosphamide therapy. Very good clinical, functional and radiomorphologic improvement was achieved in a few weeks, and remission of disease maintained in long term follow-up.

lymphomatoid granulomatosis; pulmonary nodular infiltrates; open lung biopsy; EBV+ B-lymphatic cells



Autor: Neven Rakušić - ; University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia Diana Krmpotić - ; University Hospital

Fuente: http://hrcak.srce.hr/



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