T-Lymphoblastic Lymphoma with an Unusual t8;14q24;q11 – Case ReportReportar como inadecuado

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Collegium antropologicum, Vol.34 No.1 March 2010. -

Cytogenetic abnormalities seen at presentation of acute lymphoblastic leukemia or lymphoblastic lymphoma ALL- LBL are associated with distinct clinical and hematologic disease entities. T-ALL-LBL are morphologically indistinguishable from those of B-ALL-LBL. An abnormal kariotype is found in 50–70% of cases of T-ALL-LBL. We present a 35-year old male patient with T-ALL-LBL and t8;14q24;q11.2. Our patient presented with B-symptoms, bulky mediastinal disease and CNS infiltration. Bone marrow was morphologically normal and cytogenetically without clonal aberrations. Cytological findings of the supraclavicular lymph node showed numerous CD3 positive 100% and CD2 positive 88% lymphoblasts, negative for CD34 and CD10. Flow cytometry of lymph node revealed T cell phenotype of im- mature cells: CD45+CD2+CD5+CD7+CD4+CD8+CD3cyt +CD3TdT+CD10-CD34-HLAD-DR-. Cytogenetic analysis of lymph node showed translocation t1;4p32;p12, t8;14q24;q11.2. Southern blot analysis of extracted DNA from the supraclavicular lymph node demonstrated clonal rearrangement of the T cell antigen receptor TCR-J gene region Vb+Jb2. Based on these findings, diagnosis of T lymphoblastic non Hodgkin lymphoma was established. Cerebrospinal fluid analysis showed CNS infiltration with 49% lymphoblasts positive for CD4 and CD8. The disease progressed rapidly with poor response to therapy. T-ALL-LBL with an unusual t8;14q24;q11.2 is a very rare hematologic disorder with rapid disease progression and poor response to conventional therapy because of frequent central nervous system involvement and early relapses.

T-lymphoblastic lymphoma; cytogenetics; t8; 14q24; q11.2

Autor: Inga Mandac - ; University Hospital »Merkur«, Zagreb, Croatia Slobodanka Ostojić Kolonić - ; University of Zagreb, School of

Fuente: http://hrcak.srce.hr/


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