Overexpression of ZEB2 in Peritumoral Liver Tissue Correlates with Favorable Survival after Curative Resection of Hepatocellular CarcinomaReportar como inadecuado




Overexpression of ZEB2 in Peritumoral Liver Tissue Correlates with Favorable Survival after Curative Resection of Hepatocellular Carcinoma - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

ZEB2 has been suggested to mediate EMT and disease aggressiveness in several types of human cancers. However, the expression patterns of ZEB2 in hepatocellular carcinoma HCC and its effect on prognosis of HCC patients treated with hepatectomy are unclear.

Methodology-Principal Findings

In this study, the methods of tissue microarray and immunohistochemistry IHC were utilized to investigate ZEB2 expression in HCC and peritumoral liver tissue PLT. Receiver operating characteristic ROC, spearman-s rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were used to analyze the data. Up-regulated expression of cytoplasmic-nuclear ZEB2 protein was observed in the majority of PLTs, when compared to HCCs. Further analysis showed that overexpression of cytoplasmic ZEB2 in HCCs was inversely correlated with AFP level, tumor size and differentiation P<0.05. Also, overexpression of cytoplasmic ZEB2 in PLTs correlated with lower AFP level P<0.05. In univariate survival analysis, a significant association between overexpression of cytoplasmic ZEB2 by HCCs-PLTs and longer patients- survival was found P<0.05. Importantly, cytoplasmic ZEB2 expression in PLTs was evaluated as an independent prognostic factor in multivariate analysis P<0.05. Consequently, a new clinicopathologic prognostic model with cytoplasmic ZEB2 expression including HCCs and PLTs was constructed. The model could significantly stratify risk low, intermediate and high for overall survival P = 0.002.

Conclusions-Significance

Our findings provide a basis for the concept that cytoplasmic ZEB2 expressed by PLTs can predict the postoperative survival of patients with HCC. The combined cytoplasmic ZEB2 prognostic model may become a useful tool for identifying patients with different clinical outcomes.



Autor: Mu-Yan Cai , Rong-Zhen Luo , Jie-Wei Chen , Xiao-Qing Pei, Jia-Bin Lu, Jing-Hui Hou, Jing-Ping Yun

Fuente: http://plos.srce.hr/



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