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Croatian medical journal, Vol.50 No.6 December 2009. -

Aim To assess the association between ABO blood group

genotypes and genetic risk factors for thrombosis FV

Leiden, prothrombin G20210A, and methylenetetrahydrofolate

reductase C677T mutations in the Croatian population

and to determine whether genetic predisposition to

thrombotic risk is higher in non-OO blood group genotypes

than in OO blood group genotypes.

Methods The study included 154 patients with thrombosis

and 200 asymptomatic blood donors as a control group.

Genotyping to 5 common alleles of ABO blood groups was

performed by polymerase chain reaction with sequence

specific primers PCR-SSP. FV Leiden was determined by

PCR-SSP, while prothrombin and methylenetetrahydrofolate

reductase were determined by PCR and restriction

fragment length polymorphism PCR-RFLP.

Results There was an association between non-OO blood

group genotypes and the risk of thrombosis odds ratio

OR 2.08, 95% confidence interval CI, 1.32-3.27. The

strongest association with thrombotic risk was recorded

for A1B-A2B blood group genotypes OR, 2.73; 95% CI, 1.10-

6.74, followed by BB-O1B-O2B OR, 2.29; 95% CI, 1.25-4.21

and O1A1-O2A1 OR, 1.95; 95% CI, 1.15-3.31. FV Leiden increased

the risk of thrombosis 31-fold in the group of OO

carriers and fourfold in the group of non-OO carriers. There

was no significant difference in the risk of thrombosis between

OO and non-OO blood groups associated with prothrombin

mutation. Non-OO carriers positive for methylenetetrahydrofolate

reductase had a 5.7 times greater risk

of thrombosis than that recorded in OO carriers negative

for methylenetetrahydrofolate reductase.

Conclusion Study results confirmed the association of

non-OO blood group genotypes with an increased risk of

thrombosis in Croatia.

ABO blood groups; Risk of thrombosis; Croatian population; Genetic risk factors for thrombosis; ABO blood genotypes; FV Leiden; prothrombin G20210A; MTHFR

Autor: Irena Jukić - ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia Jasna Bingulac-Popović - ; Croatian Institute of Tr

Fuente: http://hrcak.srce.hr/


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