A Genome-Wide SNP Scan Reveals Novel Loci for Egg Production and Quality Traits in White Leghorn and Brown-Egg Dwarf LayersReportar como inadecuado




A Genome-Wide SNP Scan Reveals Novel Loci for Egg Production and Quality Traits in White Leghorn and Brown-Egg Dwarf Layers - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Availability of the complete genome sequence as well as high-density SNP genotyping platforms allows genome-wide association studies GWAS in chickens. A high-density SNP array containing 57,636 markers was employed herein to identify associated variants underlying egg production and quality traits within two lines of chickens, i.e., White Leghorn and brown-egg dwarf layers. For each individual, age at first egg AFE, first egg weight FEW, and number of eggs EN from 21 to 56 weeks of age were recorded, and egg quality traits including egg weight EW, eggshell weight ESW, yolk weight YW, eggshell thickness EST, eggshell strength ESS, albumen heightAH and Haugh unitHU were measured at 40 and 60 weeks of age. A total of 385 White Leghorn females and 361 brown-egg dwarf dams were selected to be genotyped. The genome-wide scan revealed 8 SNPs showing genome-wise significant P<1.51E-06, Bonferroni correction association with egg production and quality traits under the Fisher-s combined probability method. Some significant SNPs are located in known genes including GRB14 and GALNT1 that can impact development and function of ovary, but more are located in genes with unclear functions in layers, and need to be studied further. Many chromosome-wise significant SNPs were also detected in this study and some of them are located in previously reported QTL regions. Most of loci detected in this study are novel and the follow-up replication studies may be needed to further confirm the functional significance for these newly identified SNPs.



Autor: Wenbo Liu, Dongfeng Li, Jianfeng Liu, Sirui Chen, Lujiang Qu, Jiangxia Zheng, Guiyun Xu, Ning Yang

Fuente: http://plos.srce.hr/



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