Comparison of Perfusion Weighted Magnetic Resonance Imaging and Single Photon Emission Computed Tomography for Assessment of Cerebrovascular Reserve in Symptomatic Carotid Territory StenosisReportar como inadecuado




Comparison of Perfusion Weighted Magnetic Resonance Imaging and Single Photon Emission Computed Tomography for Assessment of Cerebrovascular Reserve in Symptomatic Carotid Territory Stenosis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background: Perfusion Weighted Magnetic Resonance Imaging PW-MRI and HMPAO Single Photon Emission Computed Tomography SPECT are both cerebral perfusion measurement techniques. Imaging before and after acetazolamide administration can assess cerebrovascular reserve in symptomatic haemodynamic cerebrovascular disease. We compared SPECT and PW-MRI parameters in this patient group. Methods: We identified 10 patients with haemody-namically induced symptoms and intra- or extra-cranial arterial stenoses with back-to-back acetazolamide challenge SPECT and PW-MRI, 4 of whom had resting studies. Regions of interest ROIs were applied to parameter maps using an ASPECTS template and perfusion parameters expressed relative to contralateral ROIs, giving 118 challenge and 48 resting ROIs. Results: SPECT relative cerebral blood flow rCBF correlated with PW-MRI time to peak TTP r = ?0.568, mean transit time MTT r = ?0.317, regional cerebral blood flow rCBF r = 0.299 and cerebral blood volume CBV r = 0.224. Bias between SPECT and PW-MRI rCBF was small ?0.018 with wide limits of agreement and a systematic measurement error. Pre- to post-acetazolamide PW-MRI rCBF change showed poor sensitivity and specificity for detecting change in SPECT rCBF. SPECT and PW-MRI rCBF had stronger correlation and smaller bias in unilateral stenosis than with bilateral stenosis. Conclusion: Systematic bias between techniques limits interchange- ability in cerebrovascular reserve measurement in patients with cerebrovascular stenosis.

KEYWORDS

PW-MRI; SPECT; Carotid Stenosis; Cerebrovascular Reserve

Cite this paper

S. McSorley, K. Dani, J. Patterson, D. Brennan, D. Hadley and K. Muir -Comparison of Perfusion Weighted Magnetic Resonance Imaging and Single Photon Emission Computed Tomography for Assessment of Cerebrovascular Reserve in Symptomatic Carotid Territory Stenosis,- Open Journal of Radiology, Vol. 2 No. 3, 2012, pp. 68-76. doi: 10.4236-ojrad.2012.23013.





Autor: Stephen T. McSorley, Krishna A. Dani, Jim Patterson, David Brennan, Donald M. Hadley, Keith Muir

Fuente: http://www.scirp.org/



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