EFFICACY, TOLERABILITY AND SAFETY OF TIANEPTINE IN SPECIAL POPULATIONS OF DEPRESSIVE PATIENTSReportar como inadecuado




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Psychiatria Danubina, Vol.21 No.2 March 2009. -

Background: Tianeptine, a new generation antidepressant, possesses a unique mechanism of antidepressive action and has a specific pharmacokinetic profile. The aim of this study was to determine the efficacy, tolerability and safety of tianeptine in a -fragile- population of depressive patients: 1 a group of elderly patients and 2 a group with comorbid alcohol addiction.

Subjects and methods: This was an open multicentric eight-week study of tianeptine efficacy, tolerability and safety including patients with mild to moderate depression DSM-IV, age ≥55 years group 1; n=45 or with comorbid alcohol addiction group 2; n=32. Assessments was made with the following rating scales; MADRS, HAM-A and CGI for efficacy and DESS for tolerability.

Results: After eight-week tianeptine therapy, remission MADRS ≤12 was established in 51.1% and 84.4% patients, respectively. On day 7, the therapy led to a significant decrease of MADRS. On endpoint, there were significant differences on HAM-A, CGI-I and CGI-S scores p



Autor: Olivera Vuković - ; Institute of Psychiatry, Clinical Centre of Serbia, Serbia Nadja P. Marić - ; Institute of Psychiatry, Clin

Fuente: http://hrcak.srce.hr/



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