APOE Genotype and Cardio-Respiratory Fitness Interact to Determine Adiposity in 8-Year-Old Children from the Tasmanian Infant Health SurveyReportar como inadecuado




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APOE plays a well established role in lipid metabolism. Animal model evidence suggests APOE may also be associated with adiposity, but this has not been thoroughly investigated in humans. We measured adiposity BMI, truncal fat mass, waist circumference, physical activity PA, cardiorespiratory fitness and APOE genotype E2, E3, E4 in 292 8-year-old children from the Tasmanian Infant Health Survey TIHS, an Australian population-based prospective birth cohort. Our aims were to examine the association of APOE with child adiposity, and to examine the interplay between this association and other measured factors. We found that APOE was associated with child lipid profiles. APOE was also associated with child adiposity measures. The association was E4 allele-specific, with adiposity lower in the E4-containing group BMI: Mean difference -0.90 kg-m2; 95% confidence intervals CI -1.51 -0.28; p = 0.004. The association of APOE4 with lower BMI differed by fitness status difference in effect p = 0.002, and was more evident among the less fit mean difference -1.78 kg-m2; 95% CI -2.74 -0.83; p<0.001. Additionally, associations between BMI and lipids were only apparent in those of lower fitness who did not carry APOE4. Similar overall findings were observed when truncal fat mass and waist circumference were used as alternative adiposity measures. APOE4 and cardiorespitatory fitness could interact to influence child adiposity. In studies addressing the genetic determinants of childhood obesity, the context of child fitness should also be taken into account.



Autor: Justine A. Ellis , Anne-Louise Ponsonby, Angela Pezic, Elizabeth Williamson, Jennifer A. Cochrane, Joanne L. Dickinson, Terence D

Fuente: http://plos.srce.hr/



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