Cell Replication and Angiogenesis in Central Nervous System Tumors and Their Relationship with the Expression of Tissue Prolactin and HyperprolactinemiaReportar como inadecuado




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This study aimed to assess the effect of intracellular prolactin ICPRL and hyperprolactinemia on cell replication, using an immunohistochemical IHC technique for Ki-67 and Mcm-2, and angiogenesis, using IHC for endoglin CD-105, in central nervous system CNS tumors. This cross-sectional study included 79 cases of surgically excised primary CNS tumors of neuroepithelial origin 41.8% of all cases: 10.2% astrocytomas, 24% glioblastomas and 7.6% oligodendrogliomas and meningeal origin 58.2% of all cases. Ki-67 and Mcm-2 indexes were calculated as a percentage of marked cells. The medians for Ki-67 and Mcm-2 indexes were significantly lower in meningiomas than in glioblastomas p < 0.001 for Ki-67 and p < 0.001 for Mcm-2 and oligodendrogliomas p < 0.001 for Ki-67 and p = 0.02 for Mcm-2. A good correlation was observed between the Ki-67 and Mcm-2 rS = 0.60 replication markers. There were no significant differences in vascular density between the different histological types. Immunohistochemistry for ICPRL was positive in 45.6% of the tumors. Serum prolactin PRL was elevated in 30.6% of the cases. Multiple regression analysis revealed no important correlation of ICPRL and serum PRL on Ki-67 and Mcm-2 indexes or vascular density. The analysis of the combined impact of ICPRL and serum PRL variables revealed a trend towards an increase in microvessel density in tumor tissue and a significant increase in cell replication markers p = 0.009 for Ki-67 and p = 0.05 for Mcm-2. PRL in tumor tissue may be one of the modulating factors of cell proliferation in the CNS.

KEYWORDS

Ki-67 Antigen; Mcm-2 Protein; Human; Endoglin Protein; Human; Prolactin; Central Nervous System Tumors

Cite this paper

D. M. D. Abech, J. F. S. Pereira-Lima, C. G. S. Leães, R. T. Meurer, L. M. Barbosa-Coutinho, N. P. Ferreira and M. C. Oliveira -Cell Replication and Angiogenesis in Central Nervous System Tumors and Their Relationship with the Expression of Tissue Prolactin and Hyperprolactinemia,- Open Journal of Pathology, Vol. 2 No. 3, 2012, pp. 50-57. doi: 10.4236-ojpathology.2012.23011.





Autor: Denise M. D. Abech, Júlia F. S. Pereira-Lima, Carolina G. S. Leães, Rosalva T. Meurer, Lígia M. Barbosa-Coutinho, Nelson P. Fe

Fuente: http://www.scirp.org/



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