AC-NP: A Novel Chimeric Peptide with Natriuretic and Vasorelaxing ActionsReportar como inadecuado

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The aim of this study was to evaluate the cardiovascular and renal activities of a newly designed natriuretic peptide NP. Here, we engineered a novel 28-amino acid chimeric peptide, termed AC-NP that combined the 17-amino acid ring of C type natriuretic peptide CNP with the 6-amino acid N-terminus and 5-amino acid C-terminus of atrial natriuretic peptide ANP. Both in vitro and in vivo experiments were performed to determine the actions of AC-NP. In normal rats, AC-NP proved to be more potentially diuretic, natriuretic and hypotensive compared with other NPs, such as ANP, CNP and vasonatrin peptide VNP, which is another man-made NP. In relaxation of isolated abdominal aorta from rat, AC-NP was equally effective to ANP, CNP and VNP. Elevated levels of 3′,5′-guanosine monophosphate cGMP in plasma and urine cGMP excretion indicated the participation of cGMP in the functions of AC-NP. Taken together, innovative designed AD-NP might be a new candidate therapeutic peptide against cardiorenal disorders.

Autor: Bao-Ying Chen , Jian-Kang Chen , Miao-Zhang Zhu , Dong-Liang Zhang, Jie-Shen Sun, Jian-Ming Pei , Hua-Song Feng, Xiao-Xing Zhu, J



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