Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agentsReport as inadecuate




Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents - Download this document for free, or read online. Document in PDF available to download.

Acta Pharmaceutica, Vol.59 No.1 March 2009. -

A series of novel 3-cyclohexyl-2-substituted hydrazino-quinazolin-43H-ones were synthesized by reacting the amino group of 3-cyclohexyl-2-hydrazino quinazolin-43H-one with a variety of aldehydes and ketones. The starting material, 3-cyclohexyl-2-hydrazino quinazolin-43H-one, was synthesized from cyclohexyl amine. Title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic behavior. The compound 3-cyclohexyl-2-1-methylbutylidene-hydrazino-3H-quinazolin-4-one 4c emerged as the most active compound of the series and is moderately more potent in its analgesic and anti-inflammatory activities compared to the reference standard diclofenac sodium. Interestingly, test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.

quinazolin-43H-one; analgesic activity; anti-inflammatory activity; ulcerogenicity



Author: VEERACHAMY ALAGARSAMY - ; Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy-502294, India DURAIRAJ SHA

Source: http://hrcak.srce.hr/



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