Circulating Vascular Progenitor Cells and Central Arterial Stiffness in Polycystic Ovary SyndromeReport as inadecuate




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Objective

Subjects with Polycystic ovarian syndrome PCOS are at increased risk of Type 2 diabetes mellitus T2DM. The mechanism of this enhanced risk is unclear. Circulating vascular progenitor cells VPC are immature bone marrow derived cells capable of differentiating into mature endothelial cells. VPC number-function and central arterial stiffness predict cardio-metabolic disease in at-risk populations.

Design

We studied VPC and arterial stiffness measures in non-obese PCOS subjects as compared to age and body mass index BMI matched healthy controls in a cross–sectional study.

Methods

Fourteen subjects with PCOS and 12 controls of similar age, BMI all <30 kg-m2 and metabolic profile were studied. VPC number and in vitro function were studied by flow cytometry and tube formation assays respectively. Augmentation index AIx, a measure of central arterial stiffness, and central aortic blood pressures BP were measured by applanation tonometry.

Results

Subjects with PCOS had a reduced number, mean±SEM, of circulating CD34+133+ VPCs 317.5±51.0 vs. 558.3±101.2, p = 0.03 and impaired in vitro tube formation completed tube area 1.0±0.06 vs. 1.2±0.05×106 µm2 p = 0.02. PCOS subjects had significantly higher AIx 18.4±1.9% vs. 4.9±2.0% and this difference remained significant even after adjustments for age, BMI and smoking p = 0.003 in multivariate analyses. Central systolic and pulse pressure were higher in PCOS subjects but these differences were not statistically significant after adjustment for age. Brachial systolic and pulse pressures were similar. VPC number-function and arterial stiffness or BP measures were not correlated.

Conclusions

Non-obese PCOS is characterized by a reduced VPC number, impaired VPC function and increased central arterial stiffness. These changes in novel vascular risk markers may explain the enhanced risk of T2DM and CVD in PCOS.



Author: Cecile Dessapt-Baradez , Maria Reza, Ghayathri Sivakumar, Maria Hernandez-Fuentes, Kostas Markakis, Luigi Gnudi, Janaka Karallied

Source: http://plos.srce.hr/



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