Study on Mechanism of Preventing Tendon Adhesion by CTSb Compound MembraneReport as inadecuate




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L929 fibroblasts are cultured by blend solution of chitosan derivatives CTSb solution. The effect of the CTSb solution on L929 fibroblasts is evaluated by methods of MTT, GE and so on. The mechanism of CTSb compound membrane preventing tendon adhesion is investigated by the study on CTSb solution on L929 fibroblasts. The results show that the growth of L929 fibroblasts is inhibited obviously after cultured by CTSb solution. Along with the concentration of the CTSb solution gets higher, the inhibitory effect becomes more evident. The cell cycle of L929 fibroblasts has been discontinued and the fibroblasts are blocked in G0-G1 period. The secretion of growth factor TGF-β1 and aFGF is also inhibited by CTSb solution. The results hint that CTSb compound membrane produces its preventing adhesion effect by inhibiting the growth of fibroblasts.

KEYWORDS

chitosan; preventing adhesion; mechanism; fibroblasts

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Author: Jing Chang, Wan-shun Liu, Bao-qin Han, Ye Liang, Hai-dong Cui

Source: http://www.scirp.org/



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