PRGD-PDLLA-n-HAP Scaffolds for Peripheral Nerve Regeneration*Report as inadecuate




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An organic-inorganic composite scaffold was designed for peripheral nerve regeneration. RGD Arg-Gly-Asp grafted poly{lactic acid–co- glycolic acid-alt-L-lysine} PRGD was synthesize to promote nerve regeneration for its inducing effect on nerve cells adhesion and guidance on directional growth of axons. Inorganic nano hydroxyapatite n-HAP was induced into polymer matrix to neutralize the acidity produced by the degradation products and supply Ca2+ and PO4 3- ions for axon regeneration and protein tyrosine phosphorylation. The porosity of the obtained PRGD-PDLLA-n-HAP scaffold was about 98%. Its hydrophilicity and cell affinity were improved by n-HAP. The added HAP nanoparticles can promote the RSC96 Schwann cells adhesion, proliferation and growth both on the surface of materials and inside the scaffold.

KEYWORDS

PRGD-PDLLA-n-HAP composite; scaffolds; cell adhesion and proliferation; nerve regeneration

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Author: You-fa Wang, Yu-hua Yan, Shi-pu Li, Qiong-jiao Yan

Source: http://www.scirp.org/



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